Mice with functional humanised immune system shows promise

by IANS |

New Delhi, July 6 (IANS) A first-of-its-kind mice model with a fully functional human immune system and a human-like gut microbiome has shown promise of mounting specific antibody responses.

To date, researchers have not developed a fully functional human immune system, but only those with a brief lifespan that do not mount efficient immune responses, making them unsuitable for the development of in vivo human immunotherapies, human disease modelling, or human vaccine development.

Developed by scientists at The University of Texas in the US, the new model will overcome limitations of currently available in vivo human models and is a breakthrough for biomedical research and promises new insight into immunotherapy development and disease modelling.

Detailed in the journal Nature Immunology, the new humanised mice, called TruHuX (for truly human, or THX), possess a fully developed and fully functional human immune system, including lymph nodes, germinal centres, thymus human epithelial cells, human T and B lymphocytes, memory B lymphocytes, and plasma cells making highly specific antibody and autoantibodies identical to those of humans.

THX mice mount mature neutralising antibody responses to Salmonella Typhimurium and SARS-CoV-2 virus Spike S1 RBD after vaccination with Salmonella flagellin and the Pfizer Covid-19 mRNA vaccine, respectively.

It is also amenable to developing full-fledged systemic lupus autoimmunity after an injection of pristane -- an oil that triggers an inflammatory response.

"THX mice provide a platform for human immune system studies, development of human vaccines, and testing of therapeutics," said Paolo Casali, Professor at the University of Texas School of Medicine in San Antonio, US.

They do this "by critically leveraging oestrogen activity to support human stem cell and human immune cell differentiation and antibody responses", he added.

Latest News
FM Nirmala Sitharaman set to present her 7th Budget, major reforms expected Tue, Jul 23, 2024, 10:01 AM
Over four lakh devotees perform ongoing Amarnath Yatra in 24 days Tue, Jul 23, 2024, 09:54 AM
Tech firm Kakao's founder arrested over alleged stock manipulation Tue, Jul 23, 2024, 09:46 AM
Tour de France winner Pogacar pulls out of Paris Olympics Tue, Jul 23, 2024, 09:28 AM
What BHU students expect from Budget 2024: Funding for research, hostel, job opportunities Mon, Jul 22, 2024, 05:01 PM
Mizoram's Aizawl to become 4th state capital in NE to have rail link by next year Mon, Jul 22, 2024, 04:55 PM
Don't share video circulated by terrorists: J&K Police warns public Mon, Jul 22, 2024, 04:52 PM
Major allocations likely for six guarantees in Telangana's full budget Mon, Jul 22, 2024, 04:50 PM
Root is so special that he could eventually overtake Sachin: Vaughan Mon, Jul 22, 2024, 04:48 PM
HM Amit Shah's verbal assault on Pawar-Thackeray evoke strong reactions from MVA, NCP Mon, Jul 22, 2024, 04:46 PM
Odisha Assembly session: Oppn stages walkout during Governor's address Mon, Jul 22, 2024, 04:44 PM
14 Palestinians killed in Israeli attacks in Khan Younis: Health authorities Mon, Jul 22, 2024, 04:43 PM
No special status to Bihar, reiterates Centre in Lok Sabha; RJD takes 'toy' jibe Mon, Jul 22, 2024, 04:37 PM
AI, machine learning job roles see 433 pc rise since 2022: Study Mon, Jul 22, 2024, 04:34 PM
Typhoon Prapiroon brings rainstorms, strong gusts to China Mon, Jul 22, 2024, 04:33 PM